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Reasons to Retain TransMedics Stock in Your Portfolio for Now
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TransMedics Group, Inc. (TMDX - Free Report) is well-poised for growth in the coming quarters, courtesy of its strength in OCS technology. The optimism, led by solid first-quarter 2025 results, is expected to contribute further. However, concerns due to gross margin pressure and U.S transplant volume headwinds persist.
This Zacks Rank #3 (Hold) company has gained 97.8% in the year-to-date period against a 9.9% decline of the industry. The S&P 500 has declined 1.2% in the said time frame.
The renowned organ transplant therapy provider has a market capitalization of $4.1 billion. TransMedics’ earnings yield of 1.6% compares favorably with the industry’s (2.8%). The company’s earnings surpassed the Zacks Consensus Estimate in three of the trailing four quarters, missing once, with the average surprise being 39.1%.
Image Source: Zacks Investment Research
Factors Favoring TMDX’s Growth
Strength in OCS Technology Driving Adoption: TransMedics’ Organ Care System (OCS) revolutionizes organ transplantation by replacing passive cold storage with a dynamic, physiologic approach that perfuses donor organs with warm, oxygenated, nutrient-rich blood. This innovation minimizes ischemic injury, allows real-time organ assessment, and significantly increases the viability of organs, especially hearts and lungs, donated after circulatory death, that would otherwise go unused.
As the only FDA-approved, portable platform offering warm perfusion for heart, lung, and liver transplants, the OCS standardizes care, reduces post-transplant complications, and sets a new clinical benchmark in organ preservation. This positions TransMedics as a leader in the multi-billion-dollar transplant market with limited competition.
NOP Boosting OCS Growth Further: Complementing its technological edge, TransMedics’ National OCS Program (NOP) offers a fully integrated, end-to-end organ procurement and delivery service, accelerating adoption by streamlining logistics and clinical execution. The NOP manages OCS perfusion, provides procurement surgeons and clinical specialists, and operates a proprietary transportation network, including 21 aircraft (22 by end-2025), which supported 78% of all air transport missions, up from 75% in the fourth quarter of 2024.
By centralizing expertise and ensuring timely, controlled delivery, the NOP overcomes cold storage limitations. It extends organ viability, enabling more than 76% of liver transplants and many heart and lung surgeries to occur during daytime hours. With nearly 7,500 transplants performed in the United States and 12% of national heart and liver transplant growth in 2023 attributed to OCS and NOP, TransMedics continues to scale rapidly, reflected in the first quarter transplant logistics revenues of $26.1 million, up 80% year over year and 20% sequentially.
Solid Q1 Results: TransMedics exited first-quarter 2025 with better-than-expected results. The solid top-and-bottom-line performances and the uptick in Transplant Logistics services revenues were encouraging. The strength of both revenue sources was also impressive. The expansion of the operating margin bodes well.
Management confirmed that TransMedics plans to open a new disposables manufacturing facility in Mirandola, Italy. This will likely provide an alternate disposable manufacturing source to ensure business continuity at its Andover facility. TMDX is also planning to launch two new heart and lung clinical programs later in the year to further catalyze its growth in 2026 and beyond. These look promising for the stock.
Factors That May Offset the Gains for TMDX
Gross Margin Under Pressure: TransMedics faced mounting gross margin pressure in the first quarter of 2025 due to an increasingly unfavorable revenue mix, as rapid growth in lower-margin service offerings, particularly aviation logistics, continued to erode profitability. Overall gross margin declined 45 basis points year over year, while service gross margin dropped sharply by 632 basis points, highlighting the cost-heavy nature of scaling logistics operations. With services making up a larger share of revenue, management acknowledged limited room for margin improvement in 2025. Compounding this, scheduled aviation fleet maintenance in the second half of the year is expected to add cost burdens and introduce performance volatility, further constraining the company's ability to improve margins.
US transplant volume headwinds: TransMedics' growth faces pressure from systemic inefficiencies and policy shifts in the U.S. transplant ecosystem. Despite record transplants in 2024, changes like the 2020 liver allocation policy have reduced volumes at some centers and driven up transportation costs, straining hospital budgets and limiting demand for premium technologies like the Organ Care System, particularly in underfunded regions.
Reforms such as the OPTN Modernization Initiative and increased CMS oversight add compliance burdens and operational uncertainty. Combined with ethical scandals and fragmented systems, these challenges threaten procedural consistency and public trust, potentially slowing adoption and revenue growth despite strong long-term potential.
Estimate Trend
TransMedics is witnessing a positive estimate revision trend for 2025. In the past 30 days, the Zacks Consensus Estimate for its earnings has moved north by 33 cents to $1.89 per share.
The Zacks Consensus Estimate for the company’s second-quarter 2025 revenues is pegged at $147.4 million, indicating a 28.9% improvement from the year-ago quarter’s reported number.
Key Picks
Some better-ranked stocks in the broader medical space that have announced quarterly results are CVS Health Corporation (CVS - Free Report) , Integer Holdings Corporation (ITGR - Free Report) and AngioDynamics (ANGO - Free Report) .
Revenues of $94.59 billion outpaced the consensus mark by 1.8%. CVS Health has a long-term estimated growth rate of 11.4%. Its earnings surpassed estimates in each of the trailing four quarters, with an average surprise of 18.1%.
Integer Holdings reported first-quarter 2025 adjusted EPS of $1.31, beating the Zacks Consensus Estimate by 3.2%. Revenues of $437.4 million surpassed the Zacks Consensus Estimate by 1.3%. It currently sports a Zacks Rank #1.
Integer Holdings has a long-term estimated growth rate of 18.4%. ITGR’s earnings surpassed estimates in three of the trailing four quarters and missed once, the average surprise being 2.8%.
AngioDynamics, currently sporting a Zacks Rank #1, reported a third-quarter fiscal 2025 adjusted EPS of 3 cents against the Zacks Consensus Estimate of a 13-cent loss. Revenues of $72 million beat the Zacks Consensus Estimate by 2%.
ANGO has an estimated fiscal 2026 earnings growth rate of 27.8% compared with the S&P 500 Composite’s 10.5% growth. AngioDynamics’ earnings surpassed estimates in each of the trailing four quarters, with the average surprise being 70.9%.
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Reasons to Retain TransMedics Stock in Your Portfolio for Now
TransMedics Group, Inc. (TMDX - Free Report) is well-poised for growth in the coming quarters, courtesy of its strength in OCS technology. The optimism, led by solid first-quarter 2025 results, is expected to contribute further. However, concerns due to gross margin pressure and U.S transplant volume headwinds persist.
This Zacks Rank #3 (Hold) company has gained 97.8% in the year-to-date period against a 9.9% decline of the industry. The S&P 500 has declined 1.2% in the said time frame.
The renowned organ transplant therapy provider has a market capitalization of $4.1 billion. TransMedics’ earnings yield of 1.6% compares favorably with the industry’s (2.8%). The company’s earnings surpassed the Zacks Consensus Estimate in three of the trailing four quarters, missing once, with the average surprise being 39.1%.
Image Source: Zacks Investment Research
Factors Favoring TMDX’s Growth
Strength in OCS Technology Driving Adoption: TransMedics’ Organ Care System (OCS) revolutionizes organ transplantation by replacing passive cold storage with a dynamic, physiologic approach that perfuses donor organs with warm, oxygenated, nutrient-rich blood. This innovation minimizes ischemic injury, allows real-time organ assessment, and significantly increases the viability of organs, especially hearts and lungs, donated after circulatory death, that would otherwise go unused.
As the only FDA-approved, portable platform offering warm perfusion for heart, lung, and liver transplants, the OCS standardizes care, reduces post-transplant complications, and sets a new clinical benchmark in organ preservation. This positions TransMedics as a leader in the multi-billion-dollar transplant market with limited competition.
NOP Boosting OCS Growth Further: Complementing its technological edge, TransMedics’ National OCS Program (NOP) offers a fully integrated, end-to-end organ procurement and delivery service, accelerating adoption by streamlining logistics and clinical execution. The NOP manages OCS perfusion, provides procurement surgeons and clinical specialists, and operates a proprietary transportation network, including 21 aircraft (22 by end-2025), which supported 78% of all air transport missions, up from 75% in the fourth quarter of 2024.
By centralizing expertise and ensuring timely, controlled delivery, the NOP overcomes cold storage limitations. It extends organ viability, enabling more than 76% of liver transplants and many heart and lung surgeries to occur during daytime hours. With nearly 7,500 transplants performed in the United States and 12% of national heart and liver transplant growth in 2023 attributed to OCS and NOP, TransMedics continues to scale rapidly, reflected in the first quarter transplant logistics revenues of $26.1 million, up 80% year over year and 20% sequentially.
Solid Q1 Results: TransMedics exited first-quarter 2025 with better-than-expected results. The solid top-and-bottom-line performances and the uptick in Transplant Logistics services revenues were encouraging. The strength of both revenue sources was also impressive. The expansion of the operating margin bodes well.
Management confirmed that TransMedics plans to open a new disposables manufacturing facility in Mirandola, Italy. This will likely provide an alternate disposable manufacturing source to ensure business continuity at its Andover facility. TMDX is also planning to launch two new heart and lung clinical programs later in the year to further catalyze its growth in 2026 and beyond. These look promising for the stock.
Factors That May Offset the Gains for TMDX
Gross Margin Under Pressure: TransMedics faced mounting gross margin pressure in the first quarter of 2025 due to an increasingly unfavorable revenue mix, as rapid growth in lower-margin service offerings, particularly aviation logistics, continued to erode profitability. Overall gross margin declined 45 basis points year over year, while service gross margin dropped sharply by 632 basis points, highlighting the cost-heavy nature of scaling logistics operations. With services making up a larger share of revenue, management acknowledged limited room for margin improvement in 2025. Compounding this, scheduled aviation fleet maintenance in the second half of the year is expected to add cost burdens and introduce performance volatility, further constraining the company's ability to improve margins.
US transplant volume headwinds: TransMedics' growth faces pressure from systemic inefficiencies and policy shifts in the U.S. transplant ecosystem. Despite record transplants in 2024, changes like the 2020 liver allocation policy have reduced volumes at some centers and driven up transportation costs, straining hospital budgets and limiting demand for premium technologies like the Organ Care System, particularly in underfunded regions.
Reforms such as the OPTN Modernization Initiative and increased CMS oversight add compliance burdens and operational uncertainty. Combined with ethical scandals and fragmented systems, these challenges threaten procedural consistency and public trust, potentially slowing adoption and revenue growth despite strong long-term potential.
Estimate Trend
TransMedics is witnessing a positive estimate revision trend for 2025. In the past 30 days, the Zacks Consensus Estimate for its earnings has moved north by 33 cents to $1.89 per share.
The Zacks Consensus Estimate for the company’s second-quarter 2025 revenues is pegged at $147.4 million, indicating a 28.9% improvement from the year-ago quarter’s reported number.
Key Picks
Some better-ranked stocks in the broader medical space that have announced quarterly results are CVS Health Corporation (CVS - Free Report) , Integer Holdings Corporation (ITGR - Free Report) and AngioDynamics (ANGO - Free Report) .
CVS Health, carrying a Zacks Rank of 2 (Buy), reported first-quarter 2025 adjusted earnings per share (EPS) of $2.25, beating the Zacks Consensus Estimate by 31.6%. You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.
Revenues of $94.59 billion outpaced the consensus mark by 1.8%. CVS Health has a long-term estimated growth rate of 11.4%. Its earnings surpassed estimates in each of the trailing four quarters, with an average surprise of 18.1%.
Integer Holdings reported first-quarter 2025 adjusted EPS of $1.31, beating the Zacks Consensus Estimate by 3.2%. Revenues of $437.4 million surpassed the Zacks Consensus Estimate by 1.3%. It currently sports a Zacks Rank #1.
Integer Holdings has a long-term estimated growth rate of 18.4%. ITGR’s earnings surpassed estimates in three of the trailing four quarters and missed once, the average surprise being 2.8%.
AngioDynamics, currently sporting a Zacks Rank #1, reported a third-quarter fiscal 2025 adjusted EPS of 3 cents against the Zacks Consensus Estimate of a 13-cent loss. Revenues of $72 million beat the Zacks Consensus Estimate by 2%.
ANGO has an estimated fiscal 2026 earnings growth rate of 27.8% compared with the S&P 500 Composite’s 10.5% growth. AngioDynamics’ earnings surpassed estimates in each of the trailing four quarters, with the average surprise being 70.9%.